refTSS: A Reference Data Set for Human and Mouse Transcription Start Sites
نویسندگان
چکیده
منابع مشابه
DBTSS: DataBase of Human Transcription Start Sites, progress report 2006
DBTSS was first constructed in 2002 based on precise, experimentally determined 5' end clones. Several major updates and additions have been made since the last report. First, the number of human clones has drastically increased, going from 190,964 to 1,359,000. Second, information about potential alternative promoters is presented because the number of 5' end clones is now sufficient to determ...
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Alignments of homologous genomic sequences are widely used to identify functional genetic elements and study their evolution. Most studies tacitly equate homology of functional elements with sequence homology. This assumption is violated by the phenomenon of turnover, in which functionally equivalent elements reside at locations that are nonorthologous at the sequence level. Turnover has been d...
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and last paragraph of the intro, The claim that this is a new mechanism of retrotransposon regulation by transcription start site control is not true. The authors are apparently unaware of the work by David Garfinkel's lab on Ty1. Saha et al identified a downstream TSS that expresses a protein that inhibits Ty1 (Journal of Virology 2015, Jan 21). The downstream TSS is regulated by a subunit of ...
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MOTIVATION Identifying bacterial promoters is an important step towards understanding gene regulation. In this paper, we address the problem of predicting the location of promoters and their transcription start sites (TSSs) in Escherichia coli. The accepted method for this problem is to use position weight matrices (PWMs), which define conserved motifs at the sigma-factor binding site. However ...
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The large conductance, voltage- and Ca(2+)-activated K(+) channel plays key roles in diverse body functions influenced by estrogen, including smooth muscle and neural activities. In mouse (m), estrogen up-regulates the transcript levels of its pore-forming alpha-subunit (Slo, KCNMA1), yet the underlying genomic mechanism(s) is (are) unknown. We first mapped the promoters and regulatory motifs w...
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ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 2019
ISSN: 0022-2836
DOI: 10.1016/j.jmb.2019.04.045